New research reveals that people who discontinue popular weight-loss injections like semaglutide or tirzepatide can put back on shed pounds much more quickly than those who end conventional diet and exercise programs.
Findings released in a leading medical journal demonstrates that while overweight people frequently drop a large proportion of their body weight while using the jabs, the mass returns at an average rate of nearly a kilo each month upon discontinuation.
"Users using such medications must be aware of the risk of rapid rebound weight gain when the therapy ends," warns researcher Dr. Susan Jebb.
Such speed of regain suggests a return to original weight within about 18 months.
Comparing Approaches
The analysis, which reviewed dozens of trials involving over 9,000 of patients, contrasted the outcomes of the injectable medications with other pills.
Researchers point out that individuals who shed pounds through dieting usually see a less rapid creep back—perhaps 100 grams monthly—once they finish.
The Reason for the Fast Rebound
Experts propose the way of the drugs accounts for the amplified weight return.
These medications mimic a natural hormone called glucagon-like peptide-1, which moderates hunger.
"Long-term administration of GLP-1 levels several times higher than normal could lead to the system to produce less of its endogenous GLP-1, and may also diminish responsiveness to its actions," noted Dr. Adam Collins, a dietetics expert.
"Discontinuation of this GLP-1 'fix' leads to hunger is no longer kept in check, making excessive eating far more likely."
A Lifelong Condition?
Medical guidelines suggest the injections for people with obesity-related medical conditions, accompanied by recommended diet and exercise modifications.
Many experts argue that, considering the likelihood of relapse, the treatment should be considered long-term.
This view is echoed by pharmaceutical companies, who state that the findings "emphasize the chronic nature of excess weight," akin to managing conditions like hypertension.
User Testimonies
Individuals who have come off the medication report a sudden return of hunger.
"It was like something activating and you're instantly starving," described a patient.
This challenge is exacerbated if patients have not developed permanent lifestyle or habit changes during treatment.
Growing Adoption
Figures indicate that millions of people in the UK have tried weight-loss jabs in the past year, with demand being substantial.
- Adoption is higher among women compared to men.
- The 40s and 50s demographic shows the greatest level of interest.
- Many obtain the drugs through private prescriptions rather than public health services.
In conclusion, experts emphasize that while these medications are potent agents for weight loss, they are not a magic fix and long-term success likely depends on ongoing lifestyle management.
